Depicts an official logo of the Italian Federation for Rare Diseases (UNIAMO), surrounded by a series of small, hollow balls, indicating the rarity compared to the normality represented by a circle of larger, raised balls. Around, the inscription "Italian Republic" is closed by a star in an exergue.

Depicts the emblem of Rare Disease Day, inaugurated in 2008, and currently observed on February 29th (featuring a human silhouette cradled within hands, symbolizing unity with individuals affected by rare diseases). Encircling the emblem are inscriptions "29 February 2024" and "Rare Disease Day" positioned respectively above and below it. At the center-bottom, the denomination "5 EURO" and the designer's name "MOMONI" are displayed, while the Mint of Rome is identified with the "R" symbol located on the upper right.