Profile of Sacagawea with her infant son, Jean Baptiste Charbonneau being carried on her back.

Sacagawea (1788-1812) was a Lemhi Shoshone woman who helped the Lewis and Clark Expedition achieve each of its chartered mission objectives exploring the Louisiana Purchase. With the expedition, between 1804 and 1806, she traveled thousands of miles from North Dakota to the Pacific Ocean, established cultural contacts with Native American populations, and researched natural history.

The Lewis and Clark Expedition, also known as the Corps of Discovery Expedition, was the first American expedition to cross what is now the western portion of the United States, departing in May 1804, from near St. Louis making their way westward through the continental divide to the Pacific coast.

Engraver: Glenna Goodacre (GG)

Depicts Mary Golda Ross writing calculations. In the background, an Atlas-Agena rocket launches into space, with an equation inscribed in its cloud. The equation, denoting the energy it takes to leave Earth and reach the orbit of a distant planet, represents her important contributions to the space program. An astronaut, symbolic of Native American astronauts, including John Herrington, conducts a spacewalk above. A group of stars in the field behind indicates outer space.

Mary Golda Ross (1908–2008) was the first known Native American female engineer, and the first female engineer in the history of Lockheed. She was one of the 40 founding engineers of the renowned and highly secretive Skunk Works project at Lockheed Corporation. She worked at Lockheed from 1942 until her retirement in 1973, where she was best remembered for her work on aerospace design – including the Agena Rocket program – as well as numerous design concepts for interplanetary space travel, manned and unmanned earth-orbiting flights, the earliest studies of orbiting satellites for both defense and civilian purposes. She was the great-granddaughter of the Cherokee Chief John Ross.

The Atlas-Agena was an American expendable launch system derived from the SM-65 Atlas missile. It was a member of the Atlas family of rockets, and was launched 109 times between 1960 and 1978. It was used to launch the first five Mariner unmanned probes to the planets Venus and Mars, and the Ranger and Lunar Orbiter unmanned probes to the Moon. The upper stage was also used as an unmanned orbital target vehicle for the Gemini manned spacecraft to practice rendezvous and docking.

Artist: Emily Damstra (ESD)
Engraver: Joseph Menna (JFM)

Inscribed along the edge of the coin is the year of minting or issuance of the coin, the mint mark, and also the legend "E Pluribus Unum" (Latin for "Out of many, one").

Position A: edge lettering reads upside-down when Sacagawea's portrait (obverse) faces up.
Position B: edge lettering reads normally when Sacagawea's portrait (obverse) faces up.