Depicts a portrait of Eugenio Espejo, national coat of arms on the right, country name above.

Francisco Javier Eugenio de Santa Cruz y Espejo (1747–95) was a medical pioneer, writer and lawyer of mestizo origin in colonial Ecuador. Although he was a notable scientist and writer, he stands out as a polemicist who inspired the separatist movement in Quito. He is regarded as one of the most important figures in colonial Ecuador.

Espejo was noted in his time for being a satirist. His satirical works, inspired by the philosophy of the Age of Enlightenment, were critical of the lack of education of the Audiencia of Quito, the way the economy was being handled in the Audiencia, the corruption of its authorities, and aspects of its culture in general. Because of these works he was persecuted and finally imprisoned shortly before his death.

Denomination in digits and in words, year of issue, name of the Central Bank of Ecuador above.